Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670288 | 1.00 | MAP4K4 (0.41) | MAP4K4TRPV3EIF2AK4SCN10ACDK5 | |
| SCHEMBL20632829 | 0.90 | DGAT2 (0.41) | MAP4K4TRPV3EIF2AK4SCN10ACDK5 | |
| SCHEMBL19670613 | 0.90 | DGAT2 (0.41) | MAP4K4TRPV3EIF2AK4SCN10ACDK5 | |
| SCHEMBL17624598 | 0.90 | DGAT2 (0.41) | MAP4K4TRPV3EIF2AK4SCN10ACDK5 | |
| SCHEMBL19670203 | 0.89 | POLB (0.39) | MAP4K4TRPV3EIF2AK4SCN10ACDK5 | |
| SCHEMBL17624473 | 0.89 | POLB (0.39) | MAP4K4TRPV3EIF2AK4SCN10ACDK5 | |
| SCHEMBL19670615 | 0.88 | TRPV3 (0.40) | MAP4K4TRPV3EIF2AK4SCN10APOLB | |
| SCHEMBL17624599 | 0.88 | TRPV3 (0.40) | MAP4K4TRPV3EIF2AK4SCN10APOLB | |
| SCHEMBL19365396 | 0.88 | MAP4K4 (0.43) | MAP4K4TRPV3EIF2AK4SCN10AAR | |
| SCHEMBL19670611 | 0.88 | MAP4K4 (0.43) | MAP4K4TRPV3EIF2AK4SCN10AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2017-12-14 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | MAP4K4 1867/4885TRPV3 4464/4885EIF2AK4 1407/4885 |
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | MAP4K4 2229/4885TRPV3 4093/4885EIF2AK4 1123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.