Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365538 | 0.88 | KMT2A (0.38) | CA2CA9CCR2BACE1TSHR | |
| SCHEMBL16250002 | 0.87 | KMT2A (0.37) | CA2CA9CCR2BACE1TSHR | |
| SCHEMBL16776269 | 0.87 | CA2 (0.37) | CA2CA9CCR2BACE1FAAH | |
| SCHEMBL19706032 | 0.84 | KDM4E (0.40) | CA2CA9CCR2TSHRKMT2A | |
| SCHEMBL19365904 | 0.83 | MAPT (0.43) | CA2CA9KMT2AFAAHMAPT | |
| SCHEMBL19670185 | 0.82 | KDM4E (0.39) | CA2CA9CCR2MAPTTRPV1 | |
| SCHEMBL16785643 | 0.82 | CA2 (0.37) | CA2CA9CCR2BACE1FAAH | |
| SCHEMBL16785514 | 0.81 | KMT2A (0.37) | CA2CA9CCR2BACE1TSHR | |
| SCHEMBL19865035 | 0.81 | CA2 (0.37) | CA2CA9BACE1TSHRFAAH | |
| SCHEMBL19365540 | 0.81 | CA2 (0.38) | CA2CA9BACE1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |