Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | FSHR | P23945 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706023 | 0.91 | CA2 (0.36) | CA2CA9LMNABACE1USP2 | |
| SCHEMBL19365797 | 0.86 | TP53 (0.38) | CA2CA9LMNABACE1USP2 | |
| SCHEMBL19865035 | 0.85 | CA2 (0.37) | CA2CA9LMNABACE1USP2 | |
| SCHEMBL19365537 | 0.85 | CA2 (0.43) | CA2CA9LMNABACE1MAPT | |
| SCHEMBL19670371 | 0.84 | NAMPT (0.44) | CA2CA9LMNAUSP2POLB | |
| SCHEMBL16785514 | 0.83 | KMT2A (0.37) | CA2CA9BACE1MAPTTRPV1 | |
| SCHEMBL19670654 | 0.81 | CA2 (0.42) | CA2CA9LMNAMAPTTRPV1 | |
| SCHEMBL19670250 | 0.81 | CA2 (0.37) | CA2CA9BACE1USP2POLB | |
| SCHEMBL16785643 | 0.79 | CA2 (0.37) | CA2CA9BACE1USP2POLB | |
| SCHEMBL19365266 | 0.79 | GRIN2B (0.38) | CA2CA9LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |