Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365254 | 0.91 | HTR2C (0.47) | MAPTTRPV1FAAHMEN1KMT2A | |
| SCHEMBL19365708 | 0.91 | MAPT (0.41) | MAPTTRPV1CA2CA9MEN1 | |
| SCHEMBL19365568 | 0.89 | RHOA (0.50) | MAPTLMNAHTTMEN1ALDH1A1 | |
| SCHEMBL19365595 | 0.89 | MAPT (0.38) | MAPTLMNAHTTTRPV1CA2 | |
| SCHEMBL19670464 | 0.88 | MAPT (0.40) | MAPTLMNAHTTTRPV1CA2 | |
| SCHEMBL20632111 | 0.88 | MAPT (0.46) | MAPTLMNAHTTCA2CA9 | |
| SCHEMBL19365360 | 0.88 | CA2 (0.38) | MAPTLMNAHTTCA2CA9 | |
| SCHEMBL19365368 | 0.87 | TRPA1 (0.38) | MAPTCA2CA9MEN1ALDH1A1 | |
| SCHEMBL19365468 | 0.87 | CA2 (0.39) | MAPTLMNAHTTTRPV1CA2 | |
| SCHEMBL19365596 | 0.87 | ADORA2A (0.39) | MAPTLMNACA2CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |