Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.37 |
| ▸ | BRS3 | P32247 | 11/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394191 | 0.79 | PYGL (0.38) | BRS3 | |
| SCHEMBL14126062 | 0.76 | LPAR1 (0.47) | LTB4R2LPAR1 | |
| SCHEMBL2393996 | 0.74 | BRS3 (0.42) | BRS3 | |
| SCHEMBL1967038 | 0.74 | BRS3 (0.36) | BRS3 | |
| SCHEMBL14125960 | 0.68 | LPAR1 (0.49) | LTB4R2LPAR1 | |
| SCHEMBL14126197 | 0.67 | LPAR1 (0.45) | LTB4R2LPAR1BRS3 | |
| SCHEMBL1964718 | 0.65 | MME (0.40) | LTB4R2LPAR1BRS3 | |
| SCHEMBL2394000 | 0.64 | AGTR1 (0.40) | BRS3 | |
| SCHEMBL18589251 | 0.63 | CYP4F2 (0.48) | BRS3 | |
| SCHEMBL2392611 | 0.62 | MME (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334651-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010011821-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2010-01-28 | — | — | WO | disclosed |