Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 14/20 | 0.36 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394191 | 0.79 | PYGL (0.38) | BRS3 | |
| SCHEMBL14126064 | 0.76 | HPGDS (0.47) | BRS3 | |
| SCHEMBL1967036 | 0.74 | LTB4R2 (0.38) | BRS3 | |
| SCHEMBL2394000 | 0.67 | AGTR1 (0.40) | BRS3MMEAGTR1 | |
| SCHEMBL2393996 | 0.65 | BRS3 (0.42) | BRS3AGTR1 | |
| SCHEMBL18589251 | 0.63 | CYP4F2 (0.48) | BRS3 | |
| SCHEMBL1964718 | 0.62 | MME (0.40) | BRS3MMEAGTR1 | |
| SCHEMBL3261878 | 0.60 | OPRM1 (0.36) | AGTR1 | |
| SCHEMBL3323231 | 0.60 | NPC1 (0.35) | BRS3AGTR1 | |
| SCHEMBL7338421 | 0.59 | AGTR1 (0.48) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334651-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010011821-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2010-01-28 | — | — | WO | disclosed |