Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.39 |
| ▸ | GSK3B | P49841 | 9/20 | 0.39 |
| ▸ | WNT1 | P04628 | 9/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 4/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632880 | 0.90 | DYRK1A (0.39) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL19670564 | 0.90 | RHOA (0.46) | RHOACA2CA9BRAFRAF1 | |
| SCHEMBL19706027 | 0.89 | RHOA (0.37) | RHOABRAFKMORAF1CLK2 | |
| SCHEMBL16776357 | 0.85 | BRAF (0.40) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL19865030 | 0.85 | DYRK1A (0.40) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL19365373 | 0.84 | KMO (0.39) | CA2CA9KMO | |
| SCHEMBL17618812 | 0.82 | RHOA (0.39) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL16776298 | 0.82 | RHOA (0.39) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL16238636 | 0.82 | RHOA (0.40) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL17624498 | 0.81 | RHOA (0.40) | DYRK1AGSK3BWNT1RHOACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |