Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.39 |
| ▸ | GSK3B | P49841 | 9/20 | 0.39 |
| ▸ | WNT1 | P04628 | 9/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670427 | 0.90 | DYRK1A (0.39) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL20632034 | 0.89 | RHOA (0.41) | RHOACA2CA9BRAFCREBBP | |
| SCHEMBL19865030 | 0.86 | DYRK1A (0.40) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL16776298 | 0.86 | RHOA (0.39) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL19365508 | 0.85 | FGFR4 (0.42) | CA2CA9MAPK14KMOFGFR4 | |
| SCHEMBL20632116 | 0.83 | RHOA (0.43) | RHOABRAFPHGDHCREBBP | |
| SCHEMBL19365610 | 0.83 | BRAF (0.42) | DYRK1AGSK3BWNT1RHOABRAF | |
| SCHEMBL17655480 | 0.81 | ALOX15 (0.47) | DYRK1AGSK3BCA2CA9KMO | |
| SCHEMBL19670152 | 0.81 | RHOA (0.36) | RHOACA2CA9BRAFCREBBP | |
| SCHEMBL17624498 | 0.81 | RHOA (0.40) | DYRK1AGSK3BWNT1RHOACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |