Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 14/20 | 0.40 |
| ▸ | GSK3B | P49841 | 13/20 | 0.40 |
| ▸ | WNT1 | P04628 | 11/20 | 0.40 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19865057 | 0.89 | RHOA (0.41) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL19670328 | 0.88 | DYRK1A (0.44) | DYRK1AGSK3BWNT1 | |
| SCHEMBL19670431 | 0.88 | WNT1 (0.40) | DYRK1AGSK3BWNT1BRAF | |
| SCHEMBL17624498 | 0.86 | RHOA (0.40) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL20632880 | 0.86 | DYRK1A (0.39) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL19670492 | 0.86 | DYRK1A (0.42) | DYRK1AGSK3BWNT1 | |
| SCHEMBL16238636 | 0.85 | RHOA (0.40) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL19670427 | 0.85 | DYRK1A (0.39) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL17624504 | 0.84 | RHOA (0.43) | DYRK1AGSK3BWNT1RHOACA2 | |
| SCHEMBL19670418 | 0.84 | MPL (0.42) | CA2CA9KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044338-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044338-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | DYRK1A 2415/4885GSK3B 2465/4885WNT1 3382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.