Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365786 | 0.90 | RHOA (0.37) | RHOABRAFSLC9A1PIK3CDPIK3CA | |
| SCHEMBL19365541 | 0.89 | RHOA (0.35) | RHOABRAFFYNSLC9A1PIK3CD | |
| SCHEMBL19365668 | 0.89 | BRAF (0.43) | RHOABRAFFYNCREBBPBRD4 | |
| SCHEMBL19706136 | 0.88 | RHOA (0.43) | RHOABRAFFYNCREBBPBRD4 | |
| SCHEMBL19365806 | 0.86 | RHOA (0.42) | RHOABRAFFYNCASRPOLB | |
| SCHEMBL19365506 | 0.86 | UBE2M (0.41) | BRAFFYNPOLBRAB9AUBE2M | |
| SCHEMBL19365841 | 0.84 | PIK3CD (0.36) | FYNPOLBRAB9ALCKPIK3CD | |
| SCHEMBL19365509 | 0.83 | PHGDH (0.38) | FYNPOLBRAB9ALCKTP53 | |
| SCHEMBL19365712 | 0.83 | RHOA (0.44) | RHOABRAFFYNCREBBPBRD4 | |
| SCHEMBL19670289 | 0.82 | BRAF (0.42) | RHOABRAFFYNCREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |