Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 6/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670515 | 0.90 | WNT3A (0.35) | ABL1WNT3AMAPK1JAK3GSK3B | |
| SCHEMBL19670266 | 0.89 | FGFR4 (0.41) | ABL1WNT3AMAPK1GSK3BMTOR | |
| SCHEMBL19365270 | 0.87 | WNT3A (0.40) | ABL1WNT3AMAPK1GSK3BMTOR | |
| SCHEMBL19365654 | 0.85 | HCRTR1 (0.44) | ABL1WNT3AMAPK1 | |
| SCHEMBL19365738 | 0.85 | FGFR4 (0.37) | ABL1SMOWNT3A | |
| SCHEMBL19365276 | 0.84 | WNT3A (0.41) | ABL1WNT3AGSK3BMTOR | |
| SCHEMBL17618717 | 0.84 | SMO (0.38) | ABL1SMOWNT3AMAPK1JAK3 | |
| SCHEMBL19365620 | 0.81 | HTR2C (0.43) | ABL1WNT3AMAPK1 | |
| SCHEMBL19670328 | 0.81 | DYRK1A (0.44) | GSK3BMTOR | |
| SCHEMBL19365299 | 0.80 | FGFR4 (0.40) | WNT3AMAPK1GSK3BMTORHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |