Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365299 | 0.91 | FGFR4 (0.40) | FGFR4FAAHPDK1PDK2PDK3 | |
| SCHEMBL19670267 | 0.90 | FGFR4 (0.41) | FGFR4FAAHPDK1PDK2PDK3 | |
| SCHEMBL19670149 | 0.89 | FGFR4 (0.39) | FGFR4FAAHPDK1PDK2PDK3 | |
| SCHEMBL19670521 | 0.89 | ABL1 (0.37) | MTORABL1GSK3BHPGDSMAPK1 | |
| SCHEMBL19670515 | 0.88 | WNT3A (0.35) | MTORABL1GSK3BHPGDSMAPK1 | |
| SCHEMBL19365721 | 0.87 | FGFR4 (0.37) | FGFR4FAAHPDK1PDK2PDK3 | |
| SCHEMBL19365725 | 0.87 | FGFR4 (0.37) | FGFR4FAAHPDK1PDK2PDK3 | |
| SCHEMBL19365531 | 0.85 | FGFR4 (0.49) | FGFR4FAAHRPS6KA2ABL1CYP2C9 | |
| SCHEMBL19670334 | 0.85 | FGFR4 (0.36) | FGFR4FAAHPDK1PDK2PDK3 | |
| SCHEMBL16776028 | 0.85 | FGFR4 (0.38) | FGFR4FAAHPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |