Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16785537 | 0.87 | SCN9A (0.39) | KMOPHGDHSCN9ATRPM8KARS1 | |
| SCHEMBL16776478 | 0.87 | SCN9A (0.39) | KMOPHGDHSCN9ATRPM8KARS1 | |
| SCHEMBL16775892 | 0.84 | FGFR4 (0.42) | KMOPHGDHTLR7SCN9ATRPM8 | |
| SCHEMBL19670602 | 0.84 | SMN1; SMN2 (0.37) | KMOSMN1; SMN2CPT2CPT1ACPT1B | |
| SCHEMBL16776473 | 0.84 | FGFR4 (0.42) | KMOPHGDHTLR7SCN9ACPT2 | |
| SCHEMBL19365576 | 0.83 | KDM1A (0.41) | KMOPHGDHTLR7TRPM8JAK2 | |
| SCHEMBL16775953 | 0.79 | TRPV1 (0.44) | KMOPHGDHSCN9ASMN1; SMN2TRPM8 | |
| SCHEMBL16776124 | 0.79 | CNR2 (0.38) | KMOSMN1; SMN2RPS6KA3CNR2ALDH1A1 | |
| SCHEMBL16775838 | 0.78 | KCNH2 (0.39) | KMOSMN1; SMN2JAK2KCNH2SLC5A1 | |
| SCHEMBL16776480 | 0.78 | TRPM8 (0.42) | PHGDHTRPM8HCRTR1HCRTR2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |