Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16775854 | 0.91 | SLC5A1 (0.37) | SMN1; SMN2JAK2FYNSLC5A1CA2 | |
| SCHEMBL16775826 | 0.85 | CA2 (0.40) | JAK2FYNSLC5A1CA2CA9 | |
| SCHEMBL16785651 | 0.84 | CA2 (0.39) | FYNSLC5A1CA2CA9GSK3B | |
| SCHEMBL19670600 | 0.84 | KMO (0.38) | SMN1; SMN2JAK2SLC5A1TRPV1KMO | |
| SCHEMBL16776145 | 0.83 | TRPV3 (0.35) | SLC5A1 | |
| SCHEMBL19365333 | 0.83 | KDM1A (0.39) | SMN1; SMN2JAK2FYNCA2CA9 | |
| SCHEMBL16785576 | 0.81 | HTR2A (0.41) | SMN1; SMN2FYNCA2CA9MEN1 | |
| SCHEMBL16776333 | 0.79 | HTR2C (0.36) | FYNSLC5A1CA2CA9MEN1 | |
| SCHEMBL17618702 | 0.79 | MEN1 (0.39) | SMN1; SMN2JAK2CA2CA9MEN1 | |
| SCHEMBL17624594 | 0.78 | TRPV1 (0.39) | SMN1; SMN2JAK2FYNCA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |