Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | IL2 | P60568 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706268 | 0.94 | RHOA (0.46) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL19365660 | 0.88 | DYRK1A (0.37) | RHOABRAF | |
| SCHEMBL19365566 | 0.88 | RHOA (0.36) | RHOABRAFKDM1A | |
| SCHEMBL19706290 | 0.86 | MAPT (0.39) | FYNKDM1A | |
| SCHEMBL19706147 | 0.86 | BRAF (0.44) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL19365666 | 0.85 | HTR2C (0.41) | TRPV1 | |
| SCHEMBL19365548 | 0.83 | TRPV3 (0.37) | KDM1A | |
| SCHEMBL19670658 | 0.83 | KDM1A (0.38) | RHOABRAFFYNRAF1KDM1A | |
| SCHEMBL17618848 | 0.83 | RHOA (0.44) | RHOABRAFCREBBPBRD4FYN | |
| SCHEMBL19365787 | 0.82 | SCN10A (0.40) | FYNTRPV1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |