Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 7/20 | 0.36 |
| ▸ | MAOB | P27338 | 5/20 | 0.35 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670632 | 0.96 | RHOA (0.39) | RHOAKDM1AMAOBMAOAPIM1 | |
| SCHEMBL19670658 | 0.87 | KDM1A (0.38) | RHOAKDM1AMAOBMAOAPIM1 | |
| SCHEMBL19670436 | 0.85 | RHOA (0.42) | RHOAKDM1AMAOBMAOAJAK2 | |
| SCHEMBL16249945 | 0.83 | RHOA (0.37) | RHOAKDM1AMAOBMAOAPIM1 | |
| SCHEMBL16249976 | 0.83 | RHOA (0.39) | RHOAKDM1AMAOBMAOAKMO | |
| SCHEMBL19365318 | 0.83 | ALOX15 (0.46) | KDM1AMAOBMAOAPIM1JAK2 | |
| SCHEMBL19365576 | 0.82 | KDM1A (0.41) | KDM1AMAOBMAOAJAK2MAPT | |
| SCHEMBL17618774 | 0.82 | RHOA (0.42) | RHOAMAPTUCHL1HTR1ATRPV1 | |
| SCHEMBL19365470 | 0.82 | KDM1A (0.40) | KDM1AMAOBMAOAPIM1JAK2 | |
| SCHEMBL19365474 | 0.81 | MAPT (0.42) | KDM1AMAOBMAOAJAK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |