Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.55 |
| ▸ | ULK1 | O75385 | 1/20 | 0.51 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | BLK | P51451 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258541 | 0.89 | SYK (0.58) | SYKULK1ULK2EGFRAURKA | |
| SCHEMBL15584970 | 0.87 | ULK1 (0.51) | SYKULK1ULK2EGFRAURKA | |
| SCHEMBL19654464 | 0.79 | ULK1 (0.72) | SYKULK1ULK2EGFR | |
| SCHEMBL657592 | 0.78 | SYK (0.76) | SYKAURKA | |
| SCHEMBL19675899 | 0.77 | GRM4 (0.50) | SYKULK1ULK2EGFRTGFBR1 | |
| SCHEMBL15585219 | 0.77 | ULK1 (0.42) | SYKULK1ULK2EGFRAURKA | |
| SCHEMBL4002573 | 0.75 | SYK (0.62) | SYKULK1ULK2EGFRAURKA | |
| SCHEMBL12749854 | 0.74 | SYK (0.63) | SYKEGFRAURKABTKJAK3 | |
| SCHEMBL28504428 | 0.74 | JAK3 (0.58) | SYKEGFRAURKABTKJAK3 | |
| SCHEMBL4000667 | 0.74 | JAK3 (0.61) | SYKEGFRAURKABTKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2840080-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF | FUJIFILM CORP (JP) | 2017-12-06 | — | — | EP | disclosed |