Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.58 |
| ▸ | AURKA | O14965 | 5/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | ITK | Q08881 | 2/20 | 0.54 |
| ▸ | BTK | Q06187 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | FES | P07332 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL657592 | 0.89 | SYK (0.76) | SYKAURKAMAPK8AURKB | |
| SCHEMBL19675893 | 0.89 | SYK (0.55) | SYKAURKAKDRITKBTK | |
| SCHEMBL15584970 | 0.89 | ULK1 (0.51) | SYKAURKAKDRULK1ULK2 | |
| SCHEMBL7258580 | 0.84 | SYK (0.52) | SYKAURKAKDRCDK1CDK2 | |
| SCHEMBL4000667 | 0.84 | JAK3 (0.61) | SYKAURKAKDRCDK1CDK2 | |
| SCHEMBL15585219 | 0.81 | ULK1 (0.42) | SYKAURKAKDRSTK17AULK1 | |
| SCHEMBL655954 | 0.79 | GRM4 (0.50) | SYKAURKAKDRCDK1ERBB4 | |
| SCHEMBL4002573 | 0.79 | SYK (0.62) | SYKAURKAKDRCDK1CDK2 | |
| SCHEMBL6210503 | 0.78 | PTK2 (0.54) | SYKAURKAKDRCDK1CDK2 | |
| SCHEMBL7258709 | 0.76 | KDR (0.54) | SYKAURKAKDRCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003030909-A1 | 2- AND 4-AMINOPYRIMIDINES N-SUBSTTITUDED BY A BICYCLIC RING FOR USE AS KINASE INHIBITORS IN THE TREATMENT OF CANCER | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-17 | — | — | WO | disclosed |