Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | ESR1 | P03372 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 8/20 | 0.53 |
| ▸ | PGR | P06401 | 3/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.53 |
| ▸ | AR | P10275 | 3/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19272460 | 0.88 | MAPT (0.66) | MAPTKMT2AMEN1THRBCA2 | |
| SCHEMBL19272461 | 0.88 | MAPT (0.66) | MAPTKMT2AMEN1THRBCA2 | |
| SCHEMBL21388202 | 0.88 | MAPT (0.66) | MAPTKMT2AMEN1THRBCA2 | |
| SCHEMBL19677972 | 0.87 | MAPT (0.65) | MAPTKMT2AMEN1THRBCA2 | |
| SCHEMBL19286814 | 0.87 | MAPT (0.73) | MAPTKMT2AMEN1THRBCA2 | |
| SCHEMBL19286025 | 0.86 | MAPT (0.61) | MAPTKMT2AMEN1THRBCA2 | |
| SCHEMBL19677984 | 0.85 | CA2 (0.79) | MAPTKMT2AMEN1THRBCA2 | |
| SCHEMBL19677971 | 0.84 | CA2 (0.69) | MAPTKMT2AMEN1THRBCA2 | |
| SCHEMBL19286030 | 0.82 | MAPT (0.58) | MAPTKMT2AMEN1THRBCA2 | |
| SCHEMBL19272470 | 0.82 | MAPT (0.58) | MAPTKMT2AMEN1THRBCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019172-B1 | PRO-DRUG FORMING COMPOUNDS | EVESTRA INC (US) | 2019-09-25 | — | — | EP | disclosed |
| US-10273263-B2 | Pro-drug forming compounds | EVESTRA, INC. (US) | 2019-04-30 | — | — | US | disclosed |
| US-20170349624-A1 | PRO-DRUG FORMING COMPOUNDS | EVESTRA, INC. | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349624-A1 | PRO-DRUG FORMING COMPOUNDS | SUCNR1, FURIN, PROKR2 | MAPT 3071/4885KMT2A 2831/4885MEN1 637/4885 |
| US-10273263-B2 | Pro-drug forming compounds | SUCNR1, FURIN, OGFR | MAPT 3110/4885KMT2A 2533/4885MEN1 748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.