SCHEMBL196785

SCHEMBL196785

Clc1cccc(C(Cl)(Cl)Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.50
CYP19A1 P11511 2/20 0.46
KIF11 P52732 4/20 0.44
ALDH1A1 P00352 3/20 0.44
MAPK1 P28482 2/20 0.41
CYP3A4 P08684 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
PNMT P11086 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CHRM5 P08912 1/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C19 P33261 1/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TAAR1 Q96RJ0 1/20 0.37
PARP1 P09874 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11778847 0.91 CYP19A1 (0.49) TSHRCYP19A1KIF11ALDH1A1MAPK1
SCHEMBL9332683 0.84 CYP19A1 (0.46) TSHRCYP19A1KIF11ALDH1A1MAPK1
SCHEMBL4463685 0.84 CYP19A1 (0.46) TSHRCYP19A1KIF11ALDH1A1MAPK1
SCHEMBL1847239 0.83 TSHR (0.61) TSHRALDH1A1MAPK1CYP3A4TDP1
SCHEMBL2464063 0.81 CYP19A1 (0.42) TSHRCYP19A1KIF11ALDH1A1MAPK1
SCHEMBL28707337 0.80 ALDH1A1 (0.43) TSHRCYP19A1KIF11ALDH1A1MAPK1
SCHEMBL11469047 0.80 CYP19A1 (0.43) TSHRCYP19A1KIF11ALDH1A1MAPK1
SCHEMBL3356661 0.79 ALDH1A1 (0.50) TSHRCYP19A1KIF11ALDH1A1CYP3A4
SCHEMBL7024331 0.79 CYP19A1 (0.46) TSHRCYP19A1KIF11ALDH1A1MAPK1
SCHEMBL11862867 0.78 KIF11 (0.49) TSHRCYP19A1KIF11ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4743438-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF BENZONITRILE COMPOUNDS FROM THE BENZOTRICHLORIDE COMPOUNDS Aarti Industries Limited (IN) 2026-05-20 EP claimed
WO-2025068995-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF BENZONITRILE COMPOUNDS FROM THE BENZOTRICHLORIDE COMPOUNDS AARTI INDUSTRIES LIMITED (IN) 2025-04-03 WO claimed
US-6201152-B1 HEATING MIXTURE OF METHYL-3,5-DICHLORO-4-METHYLBENZOATE AND ALPHA,ALPHA,ALPHA-TRICHLOROMETHYLBENZENE IN PRESENCE OF AMMONIUM MOLYBDATE CATALYST OCCIDENTAL CHEMICAL CORPORATION 2001-03-13 US claimed
US-4045502-A FLUORINATION OLIN CORPORATION (US) 1977-08-30 US claimed
US-4013817-A HALOGENATED AROMATIC HYDROCARBON BRIDGESTONE TIRE COMPANY LIMITED (JA) 1977-03-22 US claimed
CN-117723687-A Method for separating and detecting related substances in o-chlorotoluene by utilizing gas chromatography 重庆华邦制药有限公司 2024-03-19 CN disclosed
CN-117723687-A Method for separating and detecting related substances in o-chlorotoluene by utilizing gas chromatography 重庆华邦制药有限公司 2024-03-19 CN disclosed
CN-116426511-A Nitrilase mutant and application thereof 浙江大学杭州国际科创中心 2023-07-14 CN disclosed
US-8293905-B2 Bipyridine compound, transition metal complex, and method for production of conjugated aromatic compound using the transition metal complex SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-23 US disclosed
US-8088883-B2 Transition metal complex and process for producing conjugated aromatic compound using the transition metal complex SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-01-03 US disclosed
US-20110046336-A1 TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING CONJUGATED AROMATIC COMPOUND USING THE TRANSITION METAL COMPLEX SUMITOMO CHEMICAL COMPANY, LIMITED 2011-02-24 US disclosed
CN-101827854-A Transition metal complex and method for producing conjugated aromatic compound using same SUMITOMO CHEMICAL CO 2010-09-08 CN disclosed
EP-0031436-B1 A METHOD FOR THE CLEAVAGE OF SILOXANES HÜLS TROISDORF AKTIENGESELLSCHAFT (DE) 1984-02-15 EP disclosed
US-4310680-A METAL OR METAL COMPOUND CATALYST DYNAMIT NOBEL AG (DE) 1982-01-12 US disclosed
EP-0031436-A2 A method for the cleavage of siloxanes HÜLS TROISDORF AKTIENGESELLSCHAFT (DE) 1981-07-08 EP disclosed
US-4212819-A Process for the preparation of benzoyl halide and halosulfonylbenzoyl halide HOOKER CHEMICALS & PLASTICS CORP. (US) 1980-07-15 US disclosed
US-4163753-A FROM AN ALIPHATIC ACID ANHYDRIDE AND A TRICHLOROMETHYL AROMATIC COMPOUND Diaz Chemical Corporation (US) 1979-08-07 US disclosed
US-4110373-A Process for the preparation of benzoyl halide and halosulfonylbenzoyl halide HOOKER CHEMICALS & PLASTICS CORP. (US) 1978-08-29 US disclosed
US-4045502-A FLUORINATION OLIN CORPORATION (US) 1977-08-30 US disclosed
US-4013817-A HALOGENATED AROMATIC HYDROCARBON BRIDGESTONE TIRE COMPANY LIMITED (JA) 1977-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110046336-A1 TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING CONJUGATED AROMATIC COMPOUND USING THE TRANSITION METAL COMPLEX C9, C5, AP1M1 TSHR 1144/4885CYP19A1 311/4885KIF11 575/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.