Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.59 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17661741 | 1.00 | ANPEP (0.59) | ANPEPFOLH1HTTTGM2MAPT | |
| SCHEMBL17646248 | 0.87 | ANPEP (0.71) | ANPEPFOLH1HTTTGM2DPP8 | |
| SCHEMBL19680371 | 0.87 | ANPEP (0.71) | ANPEPFOLH1HTTTGM2DPP8 | |
| Hydrochloric Acid SCHEMBL17646311 | 0.86 | ANPEP (0.70) | ANPEPFOLH1HTTTGM2MAPT | |
| Hydrochloric Acid SCHEMBL28344217 | 0.86 | ANPEP (0.70) | ANPEPFOLH1HTTTGM2MAPT | |
| SCHEMBL17646387 | 0.83 | ANPEP (0.53) | ANPEPFOLH1HTTTGM2MAPT | |
| SCHEMBL17250893 | 0.82 | FOLH1 (0.62) | FOLH1HTTTGM2DPP8DPP7 | |
| SCHEMBL13471242 | 0.82 | FOLH1 (0.62) | FOLH1HTTTGM2DPP8DPP7 | |
| SCHEMBL9604544 | 0.82 | FOLH1 (0.62) | FOLH1HTTTGM2DPP8DPP7 | |
| SCHEMBL17646390 | 0.82 | MAPT (0.61) | ANPEPFOLH1TGM2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988375-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170349537-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349537-A1 | INHIBITORS OF LYSINE GINGIPAIN | ENPEP, PHYKPL, PREP | ANPEP 21/4885FOLH1 216/4885HTT 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.