Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.50 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 4/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264676 | 0.74 | GRM5 (0.58) | GRM5ASIC3KDRBACE1MEN1 | |
| SCHEMBL16264688 | 0.72 | GRM5 (0.61) | GRM5ASIC3KDRMEN1KMT2A | |
| SCHEMBL19639898 | 0.70 | GRM5 (0.47) | GRM5ASIC3KDRGFERMEN1 | |
| SCHEMBL9963341 | 0.68 | TRPM8 (0.52) | TRPM8MEN1KMT2AL3MBTL1PDE10A | |
| SCHEMBL13562935 | 0.68 | TRPM8 (0.52) | GRM5ASIC3KDRTRPM8GFER | |
| SCHEMBL22593337 | 0.67 | GRM5 (0.53) | GRM5ASIC3KDRGFERMEN1 | |
| SCHEMBL5582792 | 0.67 | GRM5 (1.00) | GRM5ASIC3 | |
| SCHEMBL11970994 | 0.67 | KDR (0.57) | GRM5ASIC3KDRMEN1KMT2A | |
| SCHEMBL6466753 | 0.66 | NOS3 (0.40) | PDE10A | |
| SCHEMBL22388260 | 0.66 | HCAR3 (0.39) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017208032-A1 | COMBINATIONS COMPRISING HISTONE DEACETYLASE INHIBITORS | KARUS THERAPEUTICS LTD (GB) | 2017-12-07 | — | — | WO | disclosed |