Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 14/20 | 0.68 |
| ▸ | F11 | P03951 | 12/20 | 0.68 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21145543 | 0.81 | F11 (1.00) | KLKB1F11F2 | |
| SCHEMBL21985496 | 0.78 | KLKB1 (0.77) | KLKB1F11F2CYP3A4CYP2C8 | |
| SCHEMBL22993482 | 0.77 | KLKB1 (0.73) | KLKB1F11F2CYP3A4CYP2C8 | |
| SCHEMBL22993242 | 0.77 | KLKB1 (0.72) | KLKB1F11F2CYP3A4CYP2C8 | |
| SCHEMBL22993624 | 0.76 | KLKB1 (0.78) | KLKB1F11F2CYP3A4CYP2C8 | |
| SCHEMBL17785282 | 0.74 | F11 (1.00) | KLKB1F11F2 | |
| SCHEMBL21145591 | 0.74 | F11 (1.00) | KLKB1F11F2 | |
| SCHEMBL17786992 | 0.74 | KLKB1 (0.60) | KLKB1F11F2 | |
| SCHEMBL29324557 | 0.74 | KLKB1 (0.68) | KLKB1F11F2CYP3A4CYP2C8 | |
| SCHEMBL17786953 | 0.74 | KLKB1 (0.60) | KLKB1F11F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760622-A1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2021-01-06 | — | — | EP | disclosed |
| EP-3464271-B1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-05-13 | — | — | EP | disclosed |
| WO-2017207983-A1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2017-12-07 | — | — | WO | disclosed |