SCHEMBL19683341

SCHEMBL19683341

CC(C)(C)c1ccc(N(c2ccc(-c3ccccc3)cc2)c2ccc3cc(-c4cc5ccc6c(ccc7cc(-c8ccc9cc(N(c%10ccc(-c%11ccccc%11)cc%10)c%10ccc(C(C)(C)C)cc%10)ccc9c8)oc76)c5o4)ccc3c2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 9/20 0.38
CYP1B1 Q16678 9/20 0.38
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
CYP1A2 P05177 8/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
TP53 P04637 2/20 0.34
CYP19A1 P11511 2/20 0.34
ABCB1 P08183 2/20 0.34
ABCC1 P33527 2/20 0.34
ABCG2 Q9UNQ0 2/20 0.34
KDM4E B2RXH2 1/20 0.34
PDE5A O76074 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
MAPT P10636 1/20 0.34
CYP2C9 P11712 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31672329 1.00 CYP1A1 (0.38) CYP1A1CYP1B1MAOAMAOBCYP1A2
SCHEMBL19683540 0.96 MAOB (0.36) CYP1A1CYP1B1MAOAMAOBCYP1A2
SCHEMBL31692104 0.94 CYP1A1 (0.39) CYP1A1CYP1B1MAOAMAOBCYP1A2
SCHEMBL19683430 0.89 CYP1A1 (0.43) CYP1A1CYP1B1MAOAMAOBCYP1A2
SCHEMBL19683316 0.85 CYP26B1 (0.36) CYP1A1MAOBCYP1A2RAB9ATP53
SCHEMBL26725247 0.81 ALOX5 (0.43) MAOAMAOBNPC1RAB9AKDM4E
SCHEMBL19683342 0.80 CYP26B1 (0.39) CYP1A1CYP1B1MAOBCYP1A2TP53
SCHEMBL19683339 0.80 CYP26B1 (0.33) CYP1A1CYP1A2RAB9ATP53ABCB1
SCHEMBL19683564 0.80 CYP1A1 (0.37) CYP1A1CYP1B1MAOAMAOBCYP1A2
SCHEMBL19683432 0.78 CYP26B1 (0.41) CYP1A1CYP1B1CYP1A2ABCB1ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017210072-A1 ELECTROACTIVE COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2017-12-07 WO disclosed