Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ILK | Q13418 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23047300 | 0.86 | ERBB2 (0.47) | EGFRERBB2ALDH1A1KDM4EABL1 | |
| SCHEMBL19683692 | 0.86 | ERBB2 (0.45) | EGFRERBB2ALDH1A1KDM4EABL1 | |
| SCHEMBL19683782 | 0.84 | EGFR (0.45) | EGFRERBB2ALDH1A1KDM4EABL1 | |
| SCHEMBL20878851 | 0.83 | EGFR (0.36) | EGFRFLT3SRCSYKAURKA | |
| SCHEMBL19683611 | 0.81 | EGFR (0.45) | EGFRERBB2ALDH1A1KDM4EABL1 | |
| SCHEMBL19683604 | 0.81 | EPHX2 (0.49) | EGFRERBB2FLT3SMN1; SMN2GAA | |
| SCHEMBL19683824 | 0.80 | SRC (0.47) | EGFRERBB2ALDH1A1ABL1BCR | |
| SCHEMBL20878942 | 0.80 | EGFR (0.45) | EGFRERBB2ALDH1A1KDM4EFLT3 | |
| SCHEMBL20878968 | 0.80 | SRC (0.44) | EGFRERBB2FLT3SRCAURKA | |
| SCHEMBL19683816 | 0.79 | EGFR (0.42) | EGFRERBB2ALDH1A1KDM4EFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |