Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | ILK | Q13418 | 1/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23047300 | 0.94 | ERBB2 (0.47) | ERBB2EGFRGAASMN1; SMN2KDM4E | |
| SCHEMBL20878979 | 0.91 | ERBB2 (0.40) | ERBB2EGFRABL1BCRSRC | |
| SCHEMBL20878890 | 0.91 | BRD4 (0.45) | KDM4ELTA4HPSMB1PSMB5SYK | |
| SCHEMBL19683782 | 0.89 | EGFR (0.45) | ERBB2EGFRGAASMN1; SMN2KDM4E | |
| SCHEMBL19683824 | 0.87 | SRC (0.47) | ERBB2EGFRALDH1A1ABL1BCR | |
| SCHEMBL19683608 | 0.86 | EGFR (0.40) | ERBB2EGFRGAASMN1; SMN2KDM4E | |
| SCHEMBL19683604 | 0.86 | EPHX2 (0.49) | ERBB2EGFRGAASMN1; SMN2KDR | |
| SCHEMBL20878968 | 0.85 | SRC (0.44) | ERBB2EGFRSRCHDAC1KDR | |
| SCHEMBL20878982 | 0.84 | SMN1; SMN2 (0.45) | EGFRGAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20878942 | 0.83 | EGFR (0.45) | ERBB2EGFRGAASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |
| EP-3466952-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | Precedo Pharmaceuticals Co., Ltd. (CN) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |