Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 8/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | ILK | Q13418 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23047300 | 0.88 | ERBB2 (0.47) | SRCEGFRERBB2ILKALDH1A1 | |
| SCHEMBL19683692 | 0.87 | ERBB2 (0.45) | SRCEGFRERBB2KDREPHA2 | |
| SCHEMBL19683782 | 0.83 | EGFR (0.45) | SRCEGFRERBB2ILKAURKA | |
| SCHEMBL19683608 | 0.80 | EGFR (0.40) | SRCEGFRERBB2ILKAURKA | |
| SCHEMBL19683604 | 0.80 | EPHX2 (0.49) | EGFRERBB2KDRAURKALCK | |
| SCHEMBL20878942 | 0.80 | EGFR (0.45) | SRCEGFRERBB2KDRILK | |
| SCHEMBL20878968 | 0.79 | SRC (0.44) | SRCEGFRERBB2KDRHDAC1 | |
| SCHEMBL19683816 | 0.79 | EGFR (0.42) | SRCEGFRERBB2KDRAURKA | |
| SCHEMBL20878979 | 0.79 | ERBB2 (0.40) | SRCEGFRERBB2KDRHDAC1 | |
| SCHEMBL20878890 | 0.79 | BRD4 (0.45) | HDAC1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |