Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683920 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL19678570 | 0.84 | ALDH1A1 (0.33) | SMN1; SMN2ALDH1A1KMT2ACYP1A2KDM4E | |
| SCHEMBL19678564 | 0.84 | ALDH1A1 (0.33) | SMN1; SMN2ALDH1A1KMT2ACYP1A2KDM4E | |
| SCHEMBL3624389 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL7924840 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL3623198 | 0.71 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL21142107 | 0.71 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL10406971 | 0.70 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL3624599 | 0.70 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL3622120 | 0.70 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017214024-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2017-12-14 | — | — | WO | disclosed |
| US-20170348422-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348422-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | SHBG, EPCAM, ITGAV | SMN1; SMN2 3848/4885ALDH1A1 191/4885TDP1 4756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.