Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | RORB | Q92753 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15903182 | 0.84 | AURKA (0.51) | AURKARPS6KB1AURKBPARP1KDM4E | |
| SCHEMBL28994207 | 0.83 | AURKA (0.44) | AURKARPS6KB1AURKBPARP1KDM4E | |
| SCHEMBL3476293 | 0.82 | AURKA (0.44) | AURKARPS6KB1AURKBPARP1KDM4E | |
| SCHEMBL17895180 | 0.82 | TLR7 (0.46) | AURKAKDM4ENOS3NOS2METAP2 | |
| SCHEMBL16654073 | 0.81 | BCAT2 (0.50) | BCAT2KDM4CCSNK1A1TYRO3DYRK1B | |
| SCHEMBL29974939 | 0.79 | BCAT2 (0.51) | BCAT2KDM4CCSNK1A1TYRO3DYRK1B | |
| SCHEMBL10489526 | 0.79 | BCAT2 (0.51) | BCAT2KDM4CCSNK1A1TYRO3DYRK1B | |
| SCHEMBL18131148 | 0.79 | GRM5 (0.46) | GRM5KDM4EJAK2 | |
| SCHEMBL17894102 | 0.78 | KMT2A (0.54) | BCAT2CSNK1A1TYRO3DYRK1BPARP1 | |
| SCHEMBL30810258 | 0.78 | KMT2A (0.54) | BCAT2CSNK1A1TYRO3DYRK1BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601264-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Liao, Xibin (US) | 2020-02-05 | — | — | EP | claimed |
| EP-3555090-A1 | AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS | ARIAD Pharmaceuticals, Inc. (US) | 2019-10-23 | — | — | EP | claimed |
| WO-2018175512-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | SUZHOU BAIJIBUGONG PHARMACEUTICAL TECHNOLOGY CO. LTD. (CN) | 2018-09-27 | — | — | WO | claimed |
| WO-2018112136-A1 | AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2018-06-21 | — | — | WO | claimed |
| EP-3240542-A1 | BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-11-08 | — | — | EP | claimed |
| WO-2016109215-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-07-07 | — | — | WO | claimed |
| EP-2734523-A1 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES BTK-INHIBITORS | Merck Sharp & Dohme B.V. (NL) | 2014-05-28 | — | — | EP | claimed |
| EP-2552905-A1 | B-RAF KINASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2013-02-06 | — | — | EP | claimed |
| WO-2013010869-A1 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES BTK-INHIBITORS | MSD OSS B.V. (NL) | 2013-01-24 | — | — | WO | claimed |
| US-11974999-B2 | Bruton's tyrosine kinase inhibitors | Liao, Xibin (US) | 2024-05-07 | — | — | US | disclosed |
| CN-110964016-B | Amino-norbornane derivative and preparation method and application thereof | 南京药捷安康生物科技有限公司 | 2021-05-28 | — | — | CN | disclosed |
| CN-112135826-B | Amino-norbornane derivative and preparation method and application thereof | 南京药捷安康生物科技有限公司 | 2021-05-28 | — | — | CN | disclosed |
| US-20210121458-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Suzhou Baijibugong Pharmaceutical Technology Co., Ltd. (CN) | 2021-04-29 | — | — | US | disclosed |
| CN-112135826-A | Amino-norbornane derivative and preparation method and application thereof | 南京药捷安康生物科技有限公司 | 2020-12-25 | — | — | CN | disclosed |
| WO-2016192074-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016106627-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-07-07 | — | — | WO | disclosed |
| WO-2016106629-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-07-07 | — | — | WO | disclosed |
| WO-2016106625-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-07-07 | — | — | WO | disclosed |
| WO-2015057992-A1 | BTK INHIBITORS FOR HEMATOPOIETIC MOBILIZATION | IZUMI RAQUEL (US) | 2015-04-23 | — | — | WO | disclosed |
| EP-2334652-A1 | 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim International GmbH (DE) | 2011-06-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11974999-B2 | Bruton's tyrosine kinase inhibitors | BTK, ABL1, SYK | BCAT2 522/4885KDM4C 2197/4885AURKA 230/4885 |
| US-20210121458-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BTK, ABL1, SYK | BCAT2 522/4885KDM4C 2197/4885AURKA 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.