Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.59 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.58 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542780 | 1.00 | L3MBTL1 (0.59) | L3MBTL1MBTD1L3MBTL3LMNAHTR3E | |
| SCHEMBL2312380 | 1.00 | L3MBTL1 (0.59) | L3MBTL1MBTD1L3MBTL3LMNAHTR3E | |
| SCHEMBL93630 | 1.00 | L3MBTL1 (0.59) | L3MBTL1MBTD1L3MBTL3LMNAHTR3E | |
| Benzene SCHEMBL28818227 | 1.00 | L3MBTL1 (0.59) | L3MBTL1MBTD1L3MBTL3LMNAHTR3E | |
| Hydrochloric Acid SCHEMBL9291151 | 0.97 | ALDH1A1 (0.60) | L3MBTL1MBTD1L3MBTL3LMNAHTR3E | |
| Water SCHEMBL10922019 | 0.97 | L3MBTL1 (0.57) | L3MBTL1MBTD1L3MBTL3LMNAHTR3E | |
| Hydrochloric Acid SCHEMBL5417163 | 0.97 | ALDH1A1 (0.60) | L3MBTL1MBTD1L3MBTL3LMNAHTR3E | |
| Bromide SCHEMBL28856450 | 0.97 | L3MBTL1 (0.57) | L3MBTL1MBTD1L3MBTL3LMNAHTR3E | |
| SCHEMBL18228234 | 0.97 | L3MBTL1 (0.61) | L3MBTL1MBTD1L3MBTL3LMNAHTR3E | |
| SCHEMBL12485 | 0.97 | L3MBTL1 (0.61) | L3MBTL1MBTD1L3MBTL3LMNAHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434341-A1 | Diazine derivatives | ZENECA LIMITED (GB) | 1991-06-26 | — | — | EP | claimed |
| EP-2334683-B1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | MSD ITALIA SRL (IT) | 2017-03-22 | — | — | EP | disclosed |
| US-8470823-B2 | Saturated bicyclic heterocyclic derivatives as SMO antagonists | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2013-06-25 | — | — | US | disclosed |
| US-20110183989-A1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | Instituto di Ricerche di Biologia Molecolare P. Ang | 2011-07-28 | — | — | US | disclosed |
| EP-2334683-A1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | Istituto di ricerche di Biologia Molecolare P. Angeletti S.R.L. (IT) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010023480-A1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2010-03-04 | — | — | WO | disclosed |
| WO-2006105056-A2 | INSECTICIDAL 2,4-DIAMINOQUINAZOLINES AND RELATED DERIVATIVES | FMC CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |
| EP-0434341-B1 | Diazine derivatives | ZENECA LTD (GB) | 1995-05-17 | — | — | EP | disclosed |
| US-5252567-A | Cardiovascular disorders, sino-atrial node effects | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-12 | — | — | US | disclosed |
| EP-0262810-B1 | SHEET RECORDING MATERIAL CONTAINING DYE-FORMING COMPONENTS | Fuji Photo Film Co., Ltd. (JP) | 1992-12-09 | — | — | EP | disclosed |
| EP-0434341-A1 | Diazine derivatives | ZENECA LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |
| US-4808566-A | COLORLESS DYE IS DIMER OF 3-(4-SUBSTITUTED AMINOARYL)-3-(SUBSTITUTED INDOL-3-YL) PHTHALIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1989-02-28 | — | — | US | disclosed |
| EP-0262810-A2 | Sheet recording material containing dye-forming components | Fuji Photo Film Co., Ltd. (JP) | 1988-04-06 | — | — | EP | disclosed |
| US-4352928-A | ANTIINFLAMMATORY, HYPOGLYCEMIC, ANTICOAGULANT, ANOREXIGENIC, SEROTONIN EFFEC | MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183989-A1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | SMO, SHH, GLI1 | L3MBTL1 2984/4885MBTD1 243/4885L3MBTL3 3779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.