Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 12/20 | 0.70 |
| ▸ | CA2 | P00918 | 12/20 | 0.70 |
| ▸ | CA9 | Q16790 | 8/20 | 0.70 |
| ▸ | CA4 | P22748 | 8/20 | 0.70 |
| ▸ | CA12 | O43570 | 3/20 | 0.70 |
| ▸ | CA3 | P07451 | 3/20 | 0.70 |
| ▸ | CA6 | P23280 | 3/20 | 0.70 |
| ▸ | CA5A | P35218 | 3/20 | 0.70 |
| ▸ | CA7 | P43166 | 3/20 | 0.70 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.70 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.70 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | CA11 | O75493 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | GLS | O94925 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18100211 | 0.84 | CA1 (0.72) | CA1CA2CA9CA4CA12 | |
| SCHEMBL11561420 | 0.83 | CA2 (0.51) | CA1CA2CA9CA4CA12 | |
| SCHEMBL14194327 | 0.82 | CA1 (0.70) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL23219 | 0.82 | CA1 (1.00) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL2557036 | 0.82 | CA1 (1.00) | CA1CA2CA9CA4CA12 | |
| Hydrochloric Acid SCHEMBL10464123 | 0.82 | CA1 (0.70) | CA1CA2CA9CA4CA12 | |
| SCHEMBL17850506 | 0.81 | CA1 (0.72) | CA1CA2CA9CA4CA12 | |
| SCHEMBL11560223 | 0.81 | CA1 (0.47) | CA1CA2CA9CA4CA12 | |
| Acetazolamide Sodium SCHEMBL40813 | 0.81 | CA1 (0.68) | CA1CA2CA9CA4CA12 | |
| Acetazolamide SCHEMBL1998362 | 0.81 | CA1 (0.97) | CA1CA2CA9CA4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119241471-A | Preparation method and application of 2-acetamido-5-chlorosulfonyl-1, 3, 4-thiadiazole | 北京斯利安药业有限公司 | 2025-01-03 | — | — | CN | claimed |
| CN-115974814-B | Preparation method and application of 2-acetamido-5-chlorosulfonyl-1, 3, 4-thiadiazole | 北京斯利安药业有限公司 | 2024-08-20 | — | — | CN | claimed |
| CN-115974814-A | Preparation method and application of 2-acetamido-5-chlorosulfonyl-1, 3, 4-thiadiazole | 北京斯利安药业有限公司 | 2023-04-18 | — | — | CN | claimed |
| CN-119241471-A | Preparation method and application of 2-acetamido-5-chlorosulfonyl-1, 3, 4-thiadiazole | 北京斯利安药业有限公司 | 2025-01-03 | — | — | CN | disclosed |
| CN-119241471-A | Preparation method and application of 2-acetamido-5-chlorosulfonyl-1, 3, 4-thiadiazole | 北京斯利安药业有限公司 | 2025-01-03 | — | — | CN | disclosed |
| CN-119241471-A | Preparation method and application of 2-acetamido-5-chlorosulfonyl-1, 3, 4-thiadiazole | 北京斯利安药业有限公司 | 2025-01-03 | — | — | CN | disclosed |
| CN-115974814-B | Preparation method and application of 2-acetamido-5-chlorosulfonyl-1, 3, 4-thiadiazole | 北京斯利安药业有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-115974814-B | Preparation method and application of 2-acetamido-5-chlorosulfonyl-1, 3, 4-thiadiazole | 北京斯利安药业有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-115974814-B | Preparation method and application of 2-acetamido-5-chlorosulfonyl-1, 3, 4-thiadiazole | 北京斯利安药业有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-117447423-A | Preparation method of thiadiazolyl sulfonyl chloride compounds and thiadiazolyl sulfonamide compounds | 北京斯利安药业有限公司 | 2024-01-26 | — | — | CN | disclosed |
| WO-2023094827-A1 | SPIROCYCLIC CAV2.3 ANTAGONISTS | LARIO THERAPEUTICS LIMITED (GB) | 2023-06-01 | — | — | WO | disclosed |
| US-7582769-B2 | Dicycloalkyl urea glucokinase activators | NOVO NORDISK A/S (DK) | 2009-09-01 | — | — | US | disclosed |
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2009-05-07 | — | — | US | disclosed |
| EP-1904466-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | Novo Nordisk A/S (DK) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006760-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2007-01-18 | — | — | WO | disclosed |
| US-4940793-A | Pharmacologically active piperazino derivatives | RAVIZZA S.P.A. (IT) | 1990-07-10 | — | — | US | disclosed |
| EP-0171636-A1 | Pharmacologically active piperazino derivatives and the process for their preparation | RAVIZZA S.p.A. (IT) | 1986-02-19 | — | — | EP | disclosed |
| US-4255182-A | PRE- AND POSTEMERGENCE HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4237130-A | DIURETICS, HYPOTENSIVE AGENTS | MERCK & CO., INC. (US) | 1980-12-02 | — | — | US | disclosed |
| US-3941804-A | 1-Heteroarylsulphonyl-2-imino-imidazolidines | CIBA-GEIGY CORPORATION (US) | 1976-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118501-A1 | Dicycloalkyl Urea Glucokinase Activators | GCK, GCKR, UCK2 | CA1 3286/4885CA2 1243/4885CA9 1314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.