Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 6/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20416864 | 0.73 | KDM4E (0.46) | KDM4EALDH1A1ADORA2ANOTUMADORA1 | |
| SCHEMBL19687211 | 0.73 | S1PR2 (0.32) | ALDH1A1GAA | |
| SCHEMBL24253941 | 0.73 | KDM4E (0.42) | KDM4EALDH1A1ADORA2ANOTUMADORA1 | |
| SCHEMBL29976158 | 0.73 | KMT2A (0.49) | KDM4EALDH1A1ADORA2ANOTUMADORA1 | |
| SCHEMBL19805972 | 0.73 | KMT2A (0.49) | KDM4EALDH1A1ADORA2ANOTUMADORA1 | |
| SCHEMBL19687411 | 0.70 | IDH1 (0.39) | ADORA2AKDM6BADORA1 | |
| SCHEMBL21166232 | 0.68 | CYP1A2 (0.57) | KDM4EALDH1A1MEN1GAAMAPT | |
| SCHEMBL19687409 | 0.67 | ADORA2A (0.61) | KDM4EADORA2AMEN1LMNAGAA | |
| SCHEMBL21144033 | 0.67 | ADORA2A (0.54) | KDM4EALDH1A1ADORA2ANOTUMADORA1 | |
| SCHEMBL16506222 | 0.67 | NOTUM (0.57) | KDM4EALDH1A1ADORA2ANOTUMADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |