Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 13/20 | 0.53 |
| ▸ | GCKR | Q14397 | 5/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18549 | 0.92 | RORC (0.53) | RORCGCKRGPR119MAPT | |
| SCHEMBL12090314 | 0.89 | GPR119 (0.40) | RORCGPR119MAPT | |
| SCHEMBL18572 | 0.86 | RORC (0.56) | RORCGCKRGPR119 | |
| SCHEMBL21360346 | 0.85 | GRM5 (0.42) | GPR119MAPT | |
| SCHEMBL20078 | 0.85 | RORC (0.54) | RORCGCKR | |
| SCHEMBL19271 | 0.85 | RORC (0.47) | RORCGCKR | |
| SCHEMBL16870 | 0.84 | GCKR (0.46) | RORCGCKR | |
| SCHEMBL6719383 | 0.84 | GPR119 (0.43) | GPR119MAPT | |
| SCHEMBL6719421 | 0.84 | GPR119 (0.43) | GPR119MAPT | |
| SCHEMBL15202872 | 0.84 | RORC (0.45) | RORCGCKR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |