Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 12/20 | 0.47 |
| ▸ | GCKR | Q14397 | 2/20 | 0.41 |
| ▸ | LIPE | Q05469 | 2/20 | 0.37 |
| ▸ | MLYCD | O95822 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18549 | 0.86 | RORC (0.53) | RORCGCKR | |
| SCHEMBL19688 | 0.85 | RORC (0.53) | RORCGCKR | |
| SCHEMBL18572 | 0.79 | RORC (0.56) | RORCGCKR | |
| SCHEMBL20078 | 0.78 | RORC (0.54) | RORCGCKR | |
| SCHEMBL17126 | 0.78 | RORC (0.54) | RORCGCKR | |
| SCHEMBL15202872 | 0.76 | RORC (0.45) | RORCGCKRMLYCD | |
| SCHEMBL12089736 | 0.76 | GPR119 (0.40) | RORCGCKR | |
| SCHEMBL15202876 | 0.76 | RORC (0.44) | RORCGCKRMLYCD | |
| SCHEMBL17713 | 0.76 | GCKR (0.60) | RORCGCKRMLYCD | |
| SCHEMBL12090271 | 0.75 | PARP1 (0.43) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |