Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19639769 | 0.78 | TP53 (0.57) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL5547478 | 0.74 | GAA (0.56) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL4126168 | 0.73 | RAB9A (0.67) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL11305899 | 0.73 | MEN1 (0.44) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL8885412 | 0.72 | MAPT (0.49) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL2461958 | 0.70 | MEN1 (0.65) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL11643923 | 0.70 | CA12 (0.61) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL1189665 | 0.70 | MAPT (0.66) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL10948847 | 0.70 | MEN1 (0.59) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL30599557 | 0.70 | MAPT (0.66) | MAPTMEN1KMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017207433-A1 | HETETOCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF A DISEASE IN WHICH HNE IS IMPLICATED | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-12-07 | — | — | WO | disclosed |