Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.34 |
| ▸ | CDK2 | P24941 | 7/20 | 0.34 |
| ▸ | CDK9 | P50750 | 7/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17768178 | 0.87 | ABL1 (0.37) | ABL1NTRK1USP30MAPK1IRAK4 | |
| SCHEMBL17767957 | 0.87 | ABL1 (0.37) | ABL1NTRK1USP30MAPK1IRAK4 | |
| SCHEMBL17768095 | 0.87 | ABL1 (0.37) | ABL1NTRK1USP30MAPK1IRAK4 | |
| SCHEMBL19689790 | 0.87 | DYRK1A (0.42) | ABL1IRAK4 | |
| SCHEMBL19689684 | 0.86 | IRAK4 (0.36) | ABL1USP30MAPK1IRAK4 | |
| SCHEMBL17778649 | 0.83 | GRM5 (0.41) | ABL1GRM5 | |
| SCHEMBL19689690 | 0.83 | GRM5 (0.41) | ABL1GRM5 | |
| SCHEMBL16776487 | 0.80 | GSK3B (0.41) | ABL1GRM5 | |
| SCHEMBL17778627 | 0.79 | GRM5 (0.43) | ABL1GRM5 | |
| SCHEMBL17769501 | 0.79 | GRM5 (0.43) | ABL1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | ABL1 3898/4885GRM5 3937/4885NTRK1 4744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.