Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.33 |
| ▸ | WNT3A | P56704 | 5/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19689733 | 1.00 | RAF1 (0.33) | RAF1WNT3AMAPK1FFAR4ABL1 | |
| SCHEMBL16754425 | 0.92 | PIK3CA (0.34) | RAF1FFAR4ABL1 | |
| SCHEMBL16754514 | 0.92 | PIK3CA (0.34) | RAF1FFAR4ABL1 | |
| SCHEMBL16754515 | 0.92 | PIK3CA (0.34) | RAF1FFAR4ABL1 | |
| SCHEMBL17618758 | 0.91 | WNT3A (0.35) | RAF1WNT3AMAPK1ABL1JAK3 | |
| SCHEMBL19689757 | 0.91 | KIF18A (0.34) | RAF1WNT3AMAPK1TLR9TLR8 | |
| SCHEMBL19689755 | 0.91 | KIF18A (0.34) | RAF1WNT3AMAPK1TLR9TLR8 | |
| SCHEMBL16754445 | 0.90 | DYRK1A (0.36) | WNT3AMAPK1ABL1JAK3DYRK1A | |
| SCHEMBL17768146 | 0.90 | RAF1 (0.34) | RAF1WNT3AMAPK1ABL1JAK3 | |
| SCHEMBL19706670 | 0.90 | RAF1 (0.34) | RAF1WNT3AMAPK1ABL1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | RAF1 2078/4885WNT3A 4482/4885MAPK1 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.