Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419149 | 0.90 | JAK2 (0.53) | JAK2JAK3ALDH1A1HSD17B10HPGD | |
| SCHEMBL14130143 | 0.87 | JAK2 (0.53) | JAK2JAK3ALDH1A1HPGDRAB9A | |
| SCHEMBL5063232 | 0.84 | JAK2 (0.50) | JAK2JAK3ALDH1A1RAB9ATSHR | |
| SCHEMBL1316699 | 0.82 | GPR119 (0.43) | JAK2JAK3ALDH1A1RXFP1LMNA | |
| SCHEMBL18094323 | 0.82 | JAK2 (0.51) | JAK2JAK3ALDH1A1RAB9ATSHR | |
| SCHEMBL9010477 | 0.81 | JAK2 (0.50) | JAK2JAK3ALDH1A1HSD17B10HPGD | |
| SCHEMBL27989056 | 0.81 | LRRK2 (0.39) | JAK2JAK3ALDH1A1HSD17B10TSHR | |
| SCHEMBL12121348 | 0.80 | LMNA (0.49) | ALDH1A1HSD17B10HPGDLMNAKDM4E | |
| SCHEMBL7415910 | 0.79 | JAK2 (0.48) | JAK2JAK3ALDH1A1HPGDRAB9A | |
| SCHEMBL1363765 | 0.79 | RXFP1 (0.61) | JAK2JAK3ALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334683-A1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | Istituto di ricerche di Biologia Molecolare P. Angeletti S.R.L. (IT) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010023480-A1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2010-03-04 | — | — | WO | disclosed |