Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL31648960 | 1.00 | USP2 (0.51) | USP2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL29384 | 0.98 | USP2 (0.52) | USP2NPC1RAB9AALDH1A1HPGD | |
| Methoxymethane SCHEMBL28122245 | 0.97 | USP2 (0.51) | USP2NPC1RAB9AALDH1A1HPGD | |
| Acetic Acid SCHEMBL8064561 | 0.96 | USP2 (0.50) | USP2NPC1RAB9AALDH1A1HPGD | |
| Benzene SCHEMBL28180511 | 0.96 | USP2 (0.50) | USP2NPC1RAB9AALDH1A1HPGD | |
| Carbamic Acid SCHEMBL3710620 | 0.94 | NPC1 (0.49) | USP2NPC1RAB9AALDH1A1HPGD | |
| Phosphoric Acid SCHEMBL5699309 | 0.93 | USP2 (0.51) | USP2NPC1RAB9AALDH1A1HPGD | |
| Acrylic Acid SCHEMBL10353171 | 0.91 | USP2 (0.46) | USP2NPC1RAB9AALDH1A1HPGD | |
| Acetophenone SCHEMBL28147215 | 0.91 | LMNA (0.46) | USP2NPC1RAB9AALDH1A1HPGD | |
| Benzaldehyde SCHEMBL28180952 | 0.90 | USP2 (0.46) | USP2NPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025133603-A1 | LIQUID-PHASE PROCESS FOR PREPARING OLIGONUCLEOTIDES | Exactmer Limited (GB) | 2025-06-26 | — | — | WO | claimed |
| US-20250092082-A1 | PHOTON GENERATING SUBSTRATES FOR OLIGONUCLEOTIDE SYNTHESIS | MICROSOFT TECHNOLOGY LICENSING, LLC | 2025-03-20 | — | — | US | claimed |
| US-20180149611-A1 | BIOSENSOR AND METHOD OF FORMING PROBE ON SOLID SURFACE OF BIOSENSOR | Caduceus Biotechnology Inc. (TW) | 2018-05-31 | — | — | US | claimed |
| CN-102639552-B | RNA monomer containing O-acetal levulinyl ester group (O-acetal levulinyl ester) and application thereof in RNA microarray | THE ROYAL INSTITUTE FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2016-05-25 | — | — | CN | claimed |
| US-20160075680-A1 | MODIFIED SOLID SUPPORT FOR THE SYNTHESIS OF OLIGONUCLEOTIDES | FUNDACION IMDEA NANOCIENCIA (ES) | 2016-03-17 | — | — | US | claimed |
| EP-2992002-A1 | MODIFIED SOLID SUPPORT FOR THE SYNTHESIS OF OLIGONUCLEOTIDES | Fundación Imdea Nanociencia (ES) | 2016-03-09 | — | — | EP | claimed |
| WO-2014177533-A1 | MODIFIED SOLID SUPPORT FOR THE SYNTHESIS OF OLIGONUCLEOTIDES | FUNDACIÓN IMDEA NANOCIENCIA (ES) | 2014-11-06 | — | — | WO | claimed |
| EP-2799443-A1 | Modified solid support for the synthesis of oligonucleotides | Fundación Imdea Nanociencia (ES) | 2014-11-05 | — | — | EP | claimed |
| EP-2334692-A1 | RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS | The Royal Institution for the Advancement of Learning / McGill University (CA) | 2011-06-22 | — | — | EP | claimed |
| WO-2010025566-A1 | RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2010-03-11 | — | — | WO | claimed |
| EP-1091972-A1 | REUSABLE SOLID SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) | 2001-04-18 | — | — | EP | claimed |
| WO-2000001711-A1 | REUSABLE SOLID SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) | 2000-01-13 | — | — | WO | claimed |
| US-20260109968-A1 | A METHOD FOR SIMULTANEOUS SYNTHESIS OF A PLURALITY OF OLIGONUCLEOTIDES | ELEVEN THERAPEUTICS LTD (IL) | 2026-04-23 | — | — | US | disclosed |
| US-20250376719-A1 | METHODS OF USING MASTER / COPY ARRAYS FOR SPATIAL DETECTION | 10X GENOMICS, INC. (US) | 2025-12-11 | — | — | US | disclosed |
| EP-3894590-B1 | METHODS OF USING MASTER / COPY ARRAYS FOR SPATIAL DETECTION | 10X GENOMICS INC (US) | 2025-10-22 | — | — | EP | disclosed |
| US-12385083-B2 | Methods of using master / copy arrays for spatial detection | 10X GENOMICS, INC. (US) | 2025-08-12 | — | — | US | disclosed |
| EP-0815114-A1 | NUCLEIC ACID SYNTHESIS USING PHOTOREMOVABLE PROTECTING GROUPS | DUKE UNIVERSITY (US) | 1998-01-07 | — | — | EP | disclosed |
| WO-1997023497-A1 | LINKER ARM FOR SOLID SUPPORT OLIGONUCLEOTIDE SYNTHESIS AND PROCESS FOR PRODUCTION THEREOF | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) | 1997-07-03 | — | — | WO | disclosed |
| WO-1997023496-A1 | REUSABLE SOLID SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS, PROCESS FOR PRODUCTION THEREOF AND PROCESS FOR USE THEREOF | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) | 1997-07-03 | — | — | WO | disclosed |
| WO-1996028457-A1 | NUCLEIC ACID SYNTHESIS USING PHOTOREMOVABLE PROTECTING GROUPS | DUKE UNIVERSITY (US) | 1996-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260109968-A1 | A METHOD FOR SIMULTANEOUS SYNTHESIS OF A PLURALITY OF OLIGONUCLEOTIDES | POLL, POLM, DNMT3L | USP2 2449/4885NPC1 3472/4885RAB9A 4681/4885 |
| US-20160075680-A1 | MODIFIED SOLID SUPPORT FOR THE SYNTHESIS OF OLIGONUCLEOTIDES | POLR2H, POLRMT, POLR2E | USP2 4155/4885NPC1 2897/4885RAB9A 4813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.