Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1969371 | 0.87 | GRIA2 (0.39) | LMNALTA4HTSHRSMN1; SMN2CYP4F2 | |
| SCHEMBL2809177 | 0.81 | GRIA2 (0.47) | GRIA2FFAR1FFAR4 | |
| SCHEMBL1972442 | 0.80 | AKR1C3 (0.50) | ALDH1A1KDM4E | |
| SCHEMBL1971789 | 0.79 | MEN1 (0.40) | LTA4HGRIA2NR1H2 | |
| SCHEMBL1970202 | 0.78 | ALDH1A1 (0.40) | LMNATSHRSMN1; SMN2GRIA2ALDH1A1 | |
| SCHEMBL3761025 | 0.78 | GRIA2 (0.31) | GRIA2 | |
| Hydrochloric Acid SCHEMBL2811108 | 0.77 | ALDH1A1 (0.39) | TSHRSMN1; SMN2GRIA2ALDH1A1TDP1 | |
| SCHEMBL1973359 | 0.77 | LMNA (0.36) | LMNAGRIA2 | |
| SCHEMBL1973340 | 0.77 | LMNA (0.36) | LMNAGRIA2 | |
| SCHEMBL1970213 | 0.76 | MMP3 (0.41) | TSHRSMN1; SMN2CYP4F2CYP4A11HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236790-B2 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATORIES SERVIER (FR) | 2012-08-07 | — | — | US | claimed |
| EP-2246339-B1 | Derivatives of benzothiazepine and their use as modulators of AMPA and NMDA receptors | SERVIER LAB (FR) | 2011-06-22 | — | — | EP | claimed |
| US-20100240635-A1 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2010-09-23 | — | — | US | claimed |
| US-8236790-B2 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATORIES SERVIER (FR) | 2012-08-07 | — | — | US | disclosed |
| EP-2246339-B1 | Derivatives of benzothiazepine and their use as modulators of AMPA and NMDA receptors | SERVIER LAB (FR) | 2011-06-22 | — | — | EP | disclosed |
| EP-2246339-A1 | Derivatives of benzothiazepine and their use as modulators of AMPA and NMDA receptors | Les Laboratoires Servier (FR) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010106249-A1 | BENZOTHIADIAZEPINE DERIVATIVES USED AS AMPA AND NMDA RECEPTOR MODULATORS | LES LABORATOIRES SERVIER (FR) | 2010-09-23 | — | — | WO | disclosed |
| US-20100240635-A1 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240635-A1 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | GRIN1, GRIN2B, GRIN3A | LMNA 3593/4885LTA4H 818/4885TSHR 557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.