Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL5070662 | 0.82 | — | — | |
| SCHEMBL29402449 | 0.71 | — | — | |
| SCHEMBL30880059 | 0.71 | — | — | |
| SCHEMBL31099347 | 0.71 | — | — | |
| SCHEMBL8840579 | 0.71 | — | — | |
| Water SCHEMBL27876469 | 0.71 | — | — | |
| SCHEMBL798394 | 0.71 | — | — | |
| Water SCHEMBL23501481 | 0.50 | — | — | |
| Water SCHEMBL2335537 | 0.50 | — | — | |
| Water SCHEMBL84068 | 0.50 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250243164-A1 | PROCESS FOR PREPARING 2-[[5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL]AMINO]ACETIC ACID | AKEBIA THERAPEUTICS, INC. | 2025-07-31 | — | — | US | disclosed |
| US-12024478-B2 | Catalyst and process using the catalyst | MEXICHEM AMANCO HOLDING S.A. DE C.V. (MX) | 2024-07-02 | — | — | US | disclosed |
| CN-118271233-A | Nilaparil manufacturing method | 特沙诺有限公司 | 2024-07-02 | — | — | CN | disclosed |
| US-11629137-B2 | Methods of manufacturing of niraparib | TESARO, INC. (US) | 2023-04-18 | — | — | US | disclosed |
| CN-114096550-B | Modified nucleosides and methods of synthesis thereof | 斯微(上海)生物科技股份有限公司 | 2023-04-14 | — | — | CN | disclosed |
| CN-114096550-A | Modified nucleosides and methods of synthesis thereof | 斯微(上海)生物科技股份有限公司 | 2022-02-25 | — | — | CN | disclosed |
| US-20220041575-A1 | METHODS OF MANUFACTURING OF NIRAPARIB | TESARO, INC. | 2022-02-10 | — | — | US | disclosed |
| EP-2334427-B1 | Fluorinated FLUORINATION CATALYST AND PROCESS TO PRODUCE FLUORINATED HYDROCARBONS | MEXICHEM FLUOR SA DE CV (MX) | 2021-11-03 | — | — | EP | disclosed |
| EP-2331257-B1 | FLUORINATED FLUORINATION CATALYST AND PROCESS TO PRODUCE FLUORINATED HYDROCARBONS | MEXICHEM FLUOR SA DE CV (MX) | 2021-06-16 | — | — | EP | disclosed |
| US-20210107848-A1 | CATALYST AND PROCESS USING THE CATALYST | MEXICHEM AMANCO HOLDING S.A. DE C.V. (MX) | 2021-04-15 | — | — | US | disclosed |
| US-20170087535-A1 | CATALYST AND PROCESS USING THE CATALYST | MEXICHEM AMANCO HOLDING S.A. DE C.V. (MX) | 2017-03-30 | — | — | US | disclosed |
| US-9556079-B2 | Catalyst and process using the catalyst | MEXICHEM AMANCO HOLDING S.A. DE C.V. (MX) | 2017-01-31 | — | — | US | disclosed |
| US-20120116131-A1 | CATALYST AND PROCESS USING THE CATALYST | MEXICHEM AMANCO HOLDINGS S.A. DE C.V. (MX) | 2012-05-10 | — | — | US | disclosed |
| US-20110224466-A1 | CATALYST AND PROCESS USING THE CATALYST | MEXICHEM AMANCO HOLDINGS S.A. DE C.V. (MX) | 2011-09-15 | — | — | US | disclosed |
| EP-2334427-A2 | FLUORINATION CATALYST AND PROCESS TO PRODUCE FLUORINATED HYDROCARBONS | Mexichem Amanco Holding S.A. de C.V. (MX) | 2011-06-22 | — | — | EP | disclosed |
| EP-2331257-A2 | CATALYST AND PROCESS USING THE CATALYST | Mexichem Amanco Holding S.A. de C.V. (MX) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010026383-A2 | CATALYST AND PROCESS USING THE CATALYST | INEOS FLUOR HOLDINGS LIMITED (GB) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010026382-A2 | CATALYST AND PROCESS USING THE CATALYST | INEOS FLUOR HOLDINGS LIMITED (GB) | 2010-03-11 | — | — | WO | disclosed |
| US-7407717-B2 | Protective coating for substrates that are subjected to high temperatures and method for producing said coating | FORSCHUNGZENTRUM JULICH GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-20060099442-A1 | Protective coating for substrates that are subjected to high temperatures and method for producing said coating | FORSCHUNGSZENTRUM JULICH GMBH (DE) | 2006-05-11 | — | — | US | disclosed |