Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 9/20 | 0.67 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | TRPM2 | O94759 | 5/20 | 0.62 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6517921 | 0.81 | TRPA1 (1.00) | TRPA1TRPM8NPC1RAB9AMEN1 | |
| SCHEMBL6517926 | 0.81 | TRPA1 (1.00) | TRPA1TRPM8NPC1RAB9AMEN1 | |
| SCHEMBL2849664 | 0.81 | TRPA1 (1.00) | TRPA1TRPM8NPC1RAB9AMEN1 | |
| SCHEMBL2849668 | 0.81 | TRPA1 (1.00) | TRPA1TRPM8NPC1RAB9AMEN1 | |
| SCHEMBL294402 | 0.80 | TRPM2 (0.83) | TRPA1TRPM8NPC1RAB9AMEN1 | |
| SCHEMBL294403 | 0.80 | TRPM2 (0.83) | TRPA1TRPM8NPC1RAB9AMEN1 | |
| SCHEMBL2780698 | 0.79 | TRPA1 (1.00) | TRPA1TRPM8NPC1RAB9AMEN1 | |
| SCHEMBL2780699 | 0.79 | TRPA1 (1.00) | TRPA1TRPM8NPC1RAB9AMEN1 | |
| SCHEMBL29401064 | 0.79 | TRPM2 (0.81) | TRPA1TRPM8NPC1RAB9AMEN1 | |
| SCHEMBL2778920 | 0.79 | TRPM2 (0.81) | TRPA1TRPM8NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3485883-A1 | METHODS OF TREATING EYE DISEASES ASSOCIATED WITH INFLAMMATION AND VASCULAR PROLIFERATION | OccuRx Pty Ltd (AU) | 2019-05-22 | — | — | EP | disclosed |
| US-9839640-B2 | Methods of treating eye diseases associated with inflammation and vascular proliferation | OCCURX PTY LTD (AU) | 2017-12-12 | — | — | US | disclosed |