Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | HTR2C | P28335 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | BCR | P11274 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19699063 | 1.00 | HTR2A (0.44) | HTR2AHTR2CALDH1A1MAPTKMT2A | |
| SCHEMBL19699039 | 0.95 | HTR2C (0.46) | HTR2AHTR2CALDH1A1MAPTGAA | |
| SCHEMBL17618725 | 0.92 | ALDH1A1 (0.43) | HTR2AHTR2CALDH1A1MAPTKMT2A | |
| SCHEMBL17618673 | 0.92 | PIM3 (0.47) | HTR2AHTR2CALDH1A1MAPTPIM3 | |
| SCHEMBL19699050 | 0.91 | KMT2A (0.41) | ALDH1A1MAPTKMT2ATSHRPIM3 | |
| SCHEMBL17618630 | 0.90 | TSHR (0.45) | HTR2AHTR2CALDH1A1MAPTKMT2A | |
| SCHEMBL16776482 | 0.89 | ALDH1A1 (0.42) | HTR2AHTR2CALDH1A1MAPTPIM3 | |
| SCHEMBL20733261 | 0.89 | KMT2A (0.42) | HTR2AHTR2CALDH1A1MAPTKMT2A | |
| SCHEMBL17618719 | 0.88 | ALDH1A1 (0.42) | HTR2AHTR2CALDH1A1MAPTKMT2A | |
| SCHEMBL19365515 | 0.88 | HTR2C (0.47) | HTR2AHTR2CALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HTR2A 4386/4885HTR2C 4651/4885ALDH1A1 1726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.