Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.50 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
| ▸ | PRCP | P42785 | 2/20 | 0.42 |
| ▸ | GLI1 | P08151 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 4/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1969951 | 1.00 | NOS2 (0.50) | NOS2NOS3NOS1PRCPGLI1 | |
| SCHEMBL7432758 | 0.82 | NOS2 (0.48) | NOS2NOS3NOS1PRCPGLI1 | |
| SCHEMBL4733722 | 0.82 | PRCP (0.44) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL4733724 | 0.82 | PRCP (0.44) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL4733728 | 0.82 | PRCP (0.44) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL4012939 | 0.80 | PRCP (0.46) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL29471063 | 0.80 | PRCP (0.42) | NOS2NOS3NOS1PRCPGLI1 | |
| SCHEMBL2496026 | 0.80 | PRCP (0.46) | NOS2NOS3NOS1PRCPGLI1 | |
| SCHEMBL4685341 | 0.80 | PRCP (0.46) | NOS2NOS3NOS1PRCPDPP4 | |
| SCHEMBL8062198 | 0.79 | NOS2 (0.46) | NOS2NOS3NOS1PRCPGLI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450841-A4 | TRI-, TETRA-, AND PENTA-PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LAB (US) | 2007-01-24 | — | — | EP | claimed |
| US-7037897-B2 | TRI-, TETRA-, and penta-peptides having antiangiogenic activity | ABBOTT LABORATORIES (US) | 2006-05-02 | — | — | US | claimed |
| EP-1450841-A2 | TRI-, TETRA-, AND PENTA-PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY | Abbott Laboratories (US) | 2004-09-01 | — | — | EP | claimed |
| US-20030109456-A1 | TRI-, TETRA-, and penta-peptides having antiangiogenic activity | ABBVIE INC. | 2003-06-12 | — | — | US | claimed |
| WO-2003037912-A2 | TRI-, TETRA-, AND PENTA-PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LABORATORIES (US) | 2003-05-08 | — | — | WO | claimed |
| US-4318905-A | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues | SYNTEX (U.S.A.) INC. (US) | 1982-03-09 | — | — | US | claimed |
| EP-2177530-B1 | Octapeptide having antiangiogenic activity | ABBOTT LAB (US) | 2011-06-22 | — | — | EP | disclosed |
| EP-2177530-A1 | Octapeptide having antiangiogenic activity | Abbott Laboratories (US) | 2010-04-21 | — | — | EP | disclosed |
| US-20080071062-A1 | TETRA-, PENTA-, HEXA- AND HEPTAPEPTIDES HAVING ANTIANGIOGENIC ACTIVITY | HAVIV FORTUNA | 2008-03-20 | — | — | US | disclosed |
| US-20070167376-A1 | Hexa-, Hepta-, and Octapeptides Having Antiangiogenic Activity | HAVIV FORTUNA | 2007-07-19 | — | — | US | disclosed |
| US-7169888-B2 | Tetra-, penta-, hexa- and heptapeptides having antiangiogenic activity | ABBOTT LABORATORIES (US) | 2007-01-30 | — | — | US | disclosed |
| EP-1450841-A4 | TRI-, TETRA-, AND PENTA-PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LAB (US) | 2007-01-24 | — | — | EP | disclosed |
| US-7122625-B2 | Hexa-, hepta-, and octapeptides having antiangiogenic activity | ABBOTT LABORATORIES (US) | 2006-10-17 | — | — | US | disclosed |
| EP-0021234-B1 | NONAPEPTIDE AND DECAPEPTIDE DERIVATIVES OF LUTEINIZING HORMONE RELEASING HORMONE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYNTEX (U.S.A.) INC. (US) | 1984-08-22 | — | — | EP | disclosed |
| EP-0042753-B1 | NONAPEPTIDE AND DECAPEPTIDE AGONISTS OF LUTEINIZING HORMONE RELEASING HORMONE CONTAINING HETEROCYCLIC AMINO ACID RESIDUES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOUNDS CONTAINING THEM, AND THEIR PHARMACEUTICAL USE | SYNTEX (U.S.A.) INC. (US) | 1984-03-21 | — | — | EP | disclosed |
| US-4338305-A | LUTEINIZING HORMONE RELEASING HORMONE; CONTRACEPTIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-07-06 | — | — | US | disclosed |
| US-4318905-A | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues | SYNTEX (U.S.A.) INC. (US) | 1982-03-09 | — | — | US | disclosed |
| EP-0042753-A1 | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues, methods for their preparation, pharmaceutical compounds containing them, and their pharmaceutical use | SYNTEX (U.S.A.) INC. (US) | 1981-12-30 | — | — | EP | disclosed |
| EP-0021234-A1 | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1981-01-07 | — | — | EP | disclosed |
| US-4234571-A | CONTRACEPTIVES, ANTIFERTILITY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1980-11-18 | — | — | US | disclosed |