Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 4/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685341 | 0.88 | PRCP (0.46) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL9070256 | 0.82 | PRCP (0.41) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL4733722 | 0.82 | PRCP (0.44) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL4733724 | 0.82 | PRCP (0.44) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL4733728 | 0.82 | PRCP (0.44) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL1969951 | 0.80 | NOS2 (0.50) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL1969952 | 0.80 | NOS2 (0.50) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL29471063 | 0.80 | PRCP (0.42) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL2496026 | 0.80 | PRCP (0.46) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL514066 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009082526-A2 | ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES & INFLAMMATION | PHARMACOPEIA, INC. (US) | 2009-07-02 | — | — | WO | disclosed |
| CN-1043641-C | hydrogenated isoquinoline derivatives | SMITHKLINE BEECHAM FARMA (IT) | 1999-06-16 | — | — | CN | disclosed |
| CN-1132510-A | Hydroisoquinoline derivatives | SMITHKLINE BEECHAM FARMA (IT) | 1996-10-02 | — | — | CN | disclosed |