Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19699588 | 1.00 | KMT2A (0.42) | KMT2ASMN1; SMN2CYP1A2LMNAKDM4E | |
| SCHEMBL19706494 | 0.85 | ADRB2 (0.44) | KMT2ASMN1; SMN2CYP1A2LMNAKDM4E | |
| SCHEMBL19706507 | 0.85 | ADRB2 (0.44) | KMT2ASMN1; SMN2CYP1A2LMNAKDM4E | |
| SCHEMBL21379432 | 0.84 | CYP1A2 (0.41) | KMT2ACYP1A2LMNAKDM4EAGTR1 | |
| SCHEMBL19699542 | 0.82 | GABRA5 (0.49) | KMT2ASMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL19699531 | 0.82 | GABRA5 (0.49) | KMT2ASMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL19699577 | 0.81 | KMT2A (0.44) | KMT2ASMN1; SMN2CYP1A2LMNAALDH1A1 | |
| SCHEMBL19699570 | 0.81 | KMT2A (0.44) | KMT2ASMN1; SMN2CYP1A2LMNAALDH1A1 | |
| SCHEMBL19699602 | 0.77 | TSHR (0.39) | KMT2ACYP1A2LMNAKDM4EAGTR1 | |
| SCHEMBL19699611 | 0.77 | TSHR (0.39) | KMT2ACYP1A2LMNAKDM4EAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | KMT2A 1922/4885SMN1; SMN2 2016/4885CYP1A2 2450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.