Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.54 |
| ▸ | PI4KA | P42356 | 1/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11616554 | 0.84 | KDM4E (0.59) | KDM4ETP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19700811 | 0.81 | KDR (0.69) | KDM4ETP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29854071 | 0.81 | KDM4E (0.68) | KDM4ETP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11616495 | 0.79 | KDM4E (0.66) | KDM4ETP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1520436 | 0.78 | KDM4E (0.64) | KDM4ETP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18499432 | 0.75 | KDM4E (0.60) | KDM4ETP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18499450 | 0.75 | KDM4E (0.74) | KDM4ETP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18499444 | 0.75 | KDM4E (0.60) | KDM4ETP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL15214873 | 0.75 | TP53 (0.79) | KDM4ETP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29487079 | 0.74 | BCDIN3D (0.53) | KDM4ERAB9AALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355700-A1 | PYRAZOLOPYRIMIDINE ANTIBACTERIAL AGENTS | NORTHERN ILLINOIS RESEARCH FOUNDATION | 2017-12-14 | — | — | US | disclosed |
| US-20170355700-A1 | PYRAZOLOPYRIMIDINE ANTIBACTERIAL AGENTS | NORTHERN ILLINOIS RESEARCH FOUNDATION | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355700-A1 | PYRAZOLOPYRIMIDINE ANTIBACTERIAL AGENTS | DHPS, FDPS, IMPDH1 | KDM4E 1149/4885TP53 4401/4885SMN1; SMN2 3851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.