Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 13/20 | 0.79 |
| ▸ | NPC1 | O15118 | 5/20 | 0.79 |
| ▸ | RAB9A | P51151 | 5/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.79 |
| ▸ | HPGD | P15428 | 3/20 | 0.79 |
| ▸ | HTT | P42858 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 8/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.78 |
| ▸ | TSHR | P16473 | 2/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.70 |
| ▸ | ALPL | P05186 | 1/20 | 0.62 |
| ▸ | XDH | P47989 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2496169 | 0.88 | TP53 (0.77) | TP53NPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL10176260 | 0.88 | TP53 (0.81) | TP53NPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL10360610 | 0.86 | NPC1 (0.73) | TP53NPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL10226093 | 0.86 | TP53 (0.73) | TP53NPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL8344591 | 0.83 | LMNA (0.74) | TP53NPC1RAB9AHSD17B10KDM4E | |
| SCHEMBL6269930 | 0.76 | XDH (0.68) | TP53NPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL19700808 | 0.75 | KDM4E (0.62) | TP53NPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL16156888 | 0.74 | MAPT (1.00) | TP53NPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL15214856 | 0.74 | KDM4E (0.81) | TP53NPC1RAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL16797492 | 0.73 | MAPT (0.82) | TP53NPC1RAB9AHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376085-B1 | COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2014-02-26 | — | — | EP | disclosed |
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |