SCHEMBL19701047

SCHEMBL19701047

CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1c1nc(-c2ccc3cc(-c4ccc(-c5cnc([C@@H]6C[C@H]7C[C@H]7N6C(=O)OCc6ccccc6)[nH]5)cc4)ccc3c2)c[nH]1

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PRCP P42785 8/20 0.37
HPGDS O60760 3/20 0.37
PRMT5 O14744 5/20 0.36
GPR119 Q8TDV5 1/20 0.36
SSTR3 P32745 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20484405 1.00 PRCP (0.37) PRCPHPGDSPRMT5GPR119SSTR3
SCHEMBL1293956 0.91 HPGDS (0.38) PRCPHPGDSSSTR3
SCHEMBL1293958 0.91 HPGDS (0.38) PRCPHPGDSSSTR3
SCHEMBL1293641 0.90 HPGDS (0.37) PRCPHPGDSSSTR3
SCHEMBL1293638 0.90 HPGDS (0.37) PRCPHPGDSSSTR3
SCHEMBL17938123 0.90 HPGDS (0.37) PRCPHPGDSSSTR3
SCHEMBL12104751 0.89 HPGDS (0.38) PRCPHPGDSSSTR3
SCHEMBL17249899 0.89 HPGDS (0.38) PRCPHPGDSSSTR3
SCHEMBL19414607 0.88 HPGDS (0.37) PRCPHPGDSSSTR3
SCHEMBL19702066 0.87 PRCP (0.34) PRCPSSTR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2499127-B1 HEPATITIS C VIRUS INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2018-09-05 EP disclosed
US-20170355689-A1 HEPATITIS C VIRUS INHIBITOR BRISTOL MYERS SQUIBB CO (US) 2017-12-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170355689-A1 HEPATITIS C VIRUS INHIBITOR HAVCR2, LIPC, PYGL PRCP 220/4885HPGDS 679/4885PRMT5 2358/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.