Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196620 | 0.87 | HCAR2 (0.43) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL2609708 | 0.84 | CA12 (0.47) | HCAR2KEAP1NFE2L2ALDH1A1POLB | |
| SCHEMBL15490807 | 0.83 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL9974266 | 0.82 | HCAR2 (0.36) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL2609697 | 0.80 | HCAR2 (0.52) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL2609707 | 0.80 | HCAR2 (0.37) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL2609719 | 0.80 | HCAR2 (0.37) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL2627702 | 0.78 | HCAR2 (0.59) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL2113304 | 0.77 | HCAR2 (0.48) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 | |
| SCHEMBL23241267 | 0.74 | ALDH1A1 (0.38) | HCAR2KEAP1NFE2L2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180000770-A1 | Methods of Treating Multiple Sclerosis | BIOGEN MA INC (US) | 2018-01-04 | — | — | US | disclosed |
| US-20170368013-A1 | Methods of Treating Multiple Sclerosis | BIOGEN MA INC. | 2017-12-28 | — | — | US | disclosed |
| US-20170354630-A1 | Methods of Treating Multiple Sclerosis | BIOGEN MA INC. | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170368013-A1 | Methods of Treating Multiple Sclerosis | FAH, FH, PML | HCAR2 1264/4885KEAP1 1718/4885NFE2L2 2166/4885 |
| US-20180000770-A1 | Methods of Treating Multiple Sclerosis | FAH, FH, PML | HCAR2 1264/4885KEAP1 1718/4885NFE2L2 2166/4885 |
| US-20170354630-A1 | Methods of Treating Multiple Sclerosis | FAH, FH, PML | HCAR2 1264/4885KEAP1 1718/4885NFE2L2 2166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.